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Bio-Identical Hormone Pellet Therapy

Bioidentical hormones can be delivered in various ways, including creams, patches, injections, sublingual, and pellets. Data supports that hormone replacement therapy with pellet implants is an effective bio-identical method to deliver hormones in both men and women. Implants, placed under the skin, consistently release small, physiologic doses of hormones. Pellet insertion has been well researched since the 1930s as one of the leading Bioidentical Hormone Replacement Therapies. When using bioidentical hormone replacement therapy, the benefits are tremendous and even protective of our health.

Hormone pellets are placed under the skin, and they consistently release small, physiologic doses of hormones. 

What Is BHRT?

  • An individualized and naturopathic approach to hormone replacement therapy, using biologically identical hormones (BHRT), which pinpoints a person’s exact hormone levels and identifies the hormones needed to balance hormonal deficiencies.
  • The differences between synthetic and biologically identical hormones are in their chemical structures and functionality. Biologically identical hormones have the same chemical composition as the hormones created naturally in the human body.

What Are BHRT Pellets?

  • Fused pellet implants are compounded using biologically identical hormones (most often estradiol or testosterone).
  • The hormones are pressed or fused into tiny cylinders (the inactive ingredient is stearic acid).

BHRT Pellet Implant History

  • Hormone replacement pellet implants have been used with great success in the U.S., Europe, and Australia since 1938.
  • Pellet implants were a popular mode of hormone administration in the U.S. until the 1970s when many oral and topical commercial products were developed. While the demand for pellets diminished in the U.S., pellet implants continued to be a prevalent mode of hormone administration throughout Europe and Australia.
  • In the last ten years, due to advances made in processes and a better understanding of the benefits of fused pellet implants for hormone replacement, this mode of hormone administration has grown in popularity in the U.S.

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Over 70 Years of Research Shows:

  • Pellet implants deliver consistent, physiologic levels of hormones.
  • The consistent and physiologic dosing has been shown to maintain and improve bone density.
  • Pellet implants are a one-time procedure. There is no more worrying about creams, injections, or supplements.
  • Due to steady absorption, there is less fluctuation of symptoms.
  • Hormones are released into the bloodstream in a way that mimics your hormone rhythm.
  • A consistent supply of hormones delivered through pellets reduces the chances of experiencing adverse side effects.
  • Pellet implants bypass the liver and don’t negatively impact clotting factors, blood pressure, lipid levels, glucose, or liver function.

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Pellets Have Been Shown to Improve:

  • Cardiovascular health
  • Sex drive and libido
  • Headaches and migraines
  • Insomnia
  • Hot flashes and menopausal symptoms
  • Mood and depression
  • Joint aches and pains
  • Diabetes
  • Muscle mass
  • Cellulite
  • Motivation
  • Mood enhancement
  • Cardiovascular protection
  • Fatigue
  • Memory
  • Mental clarity

Where Are BHRT Pellets Inserted?

  • Pellet insertion is a relatively simple in-office procedure done under local anesthesia.
  • The pellets are inserted subcutaneously (under the fatty lining of skin), either in the lower abdomen or upper buttocks through a minimal incision. Then the incision is closed with surgical glue or sterile-tape strips.
  • If inserted correctly, patients cannot feel the implants under their skin. The implants placed under the skin release small, physiologic doses of hormones consistently, which have been shown to have many benefits.

How Long Do BHRT Pellets Last?

  • Fused pellet implants typically last between 3-5 months, depending on how rapidly the hormones are metabolized.
  • After insertion of the pellets, vigorous physical activity should be avoided for 2-3 days, or as suggested by your naturopathic doctor.
  • Some patients begin to feel symptom relief within 48 hours, while others may take up to two weeks to notice a marked difference.
  • The pellets do not need to be removed as they are completely dissolved by the body.

How Do I know What Hormones I Need?

  • Before starting any hormone replacement therapy, patients should work directly with a knowledgeable naturopathic doctor to have hormone testing done to evaluate their hormone profile.
  • Based on existing hormone levels and health history, the practitioner will make a hormone replacement recommendation. Once pellets have been inserted, hormone levels will be reevaluated before the insertion of the next round of pellets.
  • After the first year of therapy, the naturopathic doctor may suggest testing less frequently based upon patient feedback and prior hormone levels.

Hormones Feel Out of Balance? Check Out Our Hormone Symptom Guide.

Hormone Symptom Guide

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Estrogen Pellets for Women

  • Estrogen is a woman’s most important hormone. Without hormone replacement therapy, the loss of estrogen puts a woman at an increased risk for premature ovarian failure, osteoporosis, heart disease, colon cancer, Alzheimer’s disease, tooth loss, impaired vision, Parkinson’s disease, and diabetes.
  • There are estrogen receptors in a variety of organs throughout the body and brain. That is why hormonal imbalance produces different symptoms, such as the loss of skin elasticity, bone shrinkage, moodiness, and cognitive decline.

Testosterone Pellets for Women

  • Testosterone hormone pellet therapy gives a female patient a boost in mental clarity and libido, as well as increased muscle tone and mass. When this hormone is at low levels, women often complain of mental confusion, weight gain, and poor muscle tone, even with regular exercise.
  • The effects of hormone deficiency on the brain, muscle, bone, heart, and metabolism can be significant without hormone replacement therapy for women, and it can be dangerous to long-term health. The brain needs normal amounts of testosterone in balance with estrogen to produce serotonin, which supports emotional balance.
  • The musculoskeletal system is also adversely affected by the loss of testosterone. By not having bio-identical hormone pellet therapy, the deficiency or imbalance of testosterone can lead to muscle atrophy, osteopenia, osteoporosis, and pain in the muscles and joints.
  • Testosterone implants have been used in women. Doses used in studies are as low as 25mg and up to 225 mg. In the United States, standard doses are 50, 75, 100, 110 mg, 125, and 150 mg. There are minimal side effects at these doses (slight increase in facial hair 20% and mild acne 5%), which may be reduced by lowering the dose if the patient chooses.

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Testosterone Hormone Pellet Therapy for Men

  • Routine doses of testosterone delivered by pellet implantation in recent studies are between 500 and 1200 mg in men. The pharmacokinetics and pharmacodynamics are well established, showing that these doses deliver reproducible physiologic levels of testosterone for 4-6 months.
  • Testosterone implants have a near linear release rate. Peak serum testosterone levels with the implants are usually seen at month one. Therapeutic testosterone levels for the first month are expected at the upper limits of normal for healthy young males (800-1100 ng/dL). By month four to five, testosterone levels drop to below 500-600 mg/dL, at which time symptoms return, and the pellets are reinserted. Each individual has their own reproducible levels where symptoms return.

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How Are Hormones Monitored During Therapy? 

  • Hormone levels will be measured and evaluated before therapy is started.
  • Women’s laboratory tests may include measurements of FSH, estradiol, testosterone, and free testosterone.
  • Men’s laboratory tests may include measurements of PSA, sensitive estradiol, testosterone, liver profile, and blood count before starting therapy.
  • Thyroid hormone levels may also be evaluated.
  • Levels will be reevaluated during hormone pellet therapy every 4-5 months, usually before insertion of the next set of pellets,
  • After the first year of therapy, hormone levels may be followed less frequently.
  • Men must notify their primary care physician and obtain a digital rectal exam each year.
  • Women are advised to continue their monthly self-breast exam and obtain a mammogram and/or pap smear as recommended by their gynecologist or primary care practitioner.

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Are There Any Side Effects?

  • Generally, there are minimal side-effects associated with the pellet implant procedure.
  • Complications include minor bleeding, bruising, infection, and pellet extrusion.
  • Other than slight bruising, these other complications are very rare. Hormone pellet therapy side-effects vary and should be discussed with your naturopathic doctor.

Can a Patient Be Allergic to the Implants?

  • Very rarely, a patient will develop a local zone of redness (3-8 cm) and itching at the site of the testosterone implant.
  • There are minimal or no tenderness and no other sign of infection. Many pellet formulations include stearic acid and PVP (povidone). Patients may react to the PVP.
  • Many patients who develop a local reaction to the implant have low cortisol levels and, upon further questioning, have symptoms of adrenal insufficiency. Cortisol testing may be recommended. If needed, 25-50mg of Benadryl works well for the itching.

Safety

  • Pellets do not have the same risk of breast cancer like synthetic progestins or synthetic Methyltestosterone.
  • Studies show a reduction in the incidence of breast cancer with the implantation of testosterone pellets, with or without estradiol pellets (Dimitrakakis 04, Tutera 09).
  • Even after over 20 years of therapy with hormone pellet therapy, the risk of breast cancer does not increase (Gambrel 06). In breast cancer survivors, hormone replacement therapy with pellet implantation does not increase the risk of cancer recurrence or death (Natrajan 02), as does estrogen in combination with the synthetic progestins (Habits Trial 04).
  • Hormone pellet therapy by implantation has an extremely low incidence of side effects (Cardoza 84, Barlow 86, Ganger 89, Pirwany 02) and a high compliance rate (Gambrell 06). It has been shown to be extremely effective in the treatment of migraine headaches (Magos 83).
  • Testosterone replacement therapy in men with subcutaneous implants (pellets) has been shown to be extremely effective, convenient, and safe. (Handelsman 90, 92, 97, Kelleher 01, 04, Conway 88, Jockenhoval 96, Zacharin 03, Schubert 03, Dunning 04).
  • A patented form of testosterone pellet with the brand name Testopel has been FDA approved since before 1982.

Sources: 

  • Cited with permission – College Pharmacy 
  • Cited with permission – Wells Pharmacy Network 

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Call 480-588-6856 to schedule a FREE
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Jill Mapstead
Jill Mapstead
2022-03-22
Can’t say enough about Dr. Marianne Marchese! Her commitment to women’s wellness, calm, knowledgeable, non-judgemental guidance and insightful diagnoses / treatment has me turn to her for all my wellness needs. She takes the time to really listen. I feel heard and valued in her care.
Marc Cohn
Marc Cohn
2022-01-08
We had a great first visit with Dr. Turner and we look forward to continuing to work with her. She provides true support and guidance to better health. Alexandra Cohn
Ivana Kalika
Ivana Kalika
2021-12-24
I'm writing my review for Dr. Sarv Varta Khalsa. I met with her a few months ago to receive treatment for a condition I'd been dealing with for an extensive amount of time. She was incredibly kind and took the time to listen to all the details of the symptoms I was experiencing. The office had the prescriptions I needed on-hand so I didn't need to go off-site to find them. All natural remedies, and at comparatively good prices (I don't remember how much exactly, but if they were up-charging, which I doubt, I didn't notice nor would I have minded for the convenience). I'm still symptom-free now after following her recommendations, so I wanted to write a review to express my gratitude. Even though the appointment was pricey, it was worth every single penny to finally be able to live my life feeling normal again. Thank you so much!!
Irene Nicholas
Irene Nicholas
2021-12-15
What's better than a Naturopathic Dr.... Dr. Olivia Watkins!!! I have been working with her for over a year and have learned so much about myself, she is truly a team partner in my journey. She is experienced in ANYTHING you may be experiencing. I consider her my primary physician... you should too!!!
Stephanie Llamas
Stephanie Llamas
2021-11-29
Dr. Watkins is nothing short of incredible. She is kind and personable, while extremely smart and results driven. I have suffered from digestive and hormonal issues my whole life and it wasn't until I met Dr. Watkins that I finally felt heard by a Dr and saw a difference in my health. I can confidently say that my body has never felt this good and we are still working to be even better. If you are ready to feel better and feel heard from your doctor, then run, don't walk to Living Wellness.
D Bach
D Bach
2021-11-10
Dr Olivia Watkins offers a beautiful aura of sincere loving support that I will forever cherish, as she exudes and radiates a beautiful light towards her patients' health care needs. Also, her staff, Joslyn and Ariana are as sweet as they come and have been as helpful as can be to me. One issue I had (and have had a few) was a lack of nutrient absorption and it was Dr Olivia who helped me change that status (thank God!) which I'm already seeing immediate results from and I've had this issue for years which my nails and hair loss were severely revealing! I've also experienced so much stress in the last year and a half, that having Dr Olivia as part of my healing process has made all the difference in my recovery to a more whole being! At this point, I seriously don't know what I'd do without her, as she is now my go-to health advocate and will be to my end days. Dr Olivia is a GodSend! Don't hesitate to call her office. High fives for the brightest healing light you could ever pray for in life! After eight long years, Dr Olivia just recently finished her GM residency and once again, I must congratulate her on such discipline and hard work as it has obviously paid off in spades! Long live Dr Olivia!
Kristin A
Kristin A
2021-09-19
I love Dr. Marchese and so glad I found her last year. She has helped me so much with my health. I have recommended her to several people and they love her too.
Kelly leibrandt
Kelly leibrandt
2021-07-28
Dr. Watkins is life changing! I am so grateful that I was referred to Living Wellness and her specifically. I’ve been dealing with severe stomach issues for 10 years and have gone through the ringer with the test, labs, and over-the-counter medicine suggested by other doctors. Dr. Watkins is so smart, thoughtful, and attentive to every detail so that she can really get down to the bottom of your problems. She feels like a teammate and a very strong coach and a friend all in one. I’m finally on my way to feeling better and I couldn’t have done this without her. If you’re struggling don’t even hesitate to see her or any of the staff at living wellness. I promise you won’t regret it!
Erica Brunkow
Erica Brunkow
2021-03-19
I saw Dr. Warkins several times and was overly impressed her. I was going through cancer treatments and she was compassionate and resourceful. We connected and I felt at such ease with her. She followed up with me multiple times to see how I was doing and feeling. I will continue to see her for any future Gyn needs.
Carey Miller
Carey Miller
2021-03-18
I began to see Dr. Watkins for some general Women's Health issues and she was incredible to work with. She helped my body become more balanced, pain was relieved naturally, and my body was prepared for a healthy pregnancy. She is kind, knowledgable, and very supportive!
Google rating score: 5 of 5, based on 27 reviews

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